Hypertension, Diuretics, and Uric Acid

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Serum Uric Acid in Primary Hypertension

Over about a quarter of a century, primary hypertension has become a rapidly growing health problem in children and adolescents. The pathogenesis of primary hypertension remains unclear and is said to involve a complex interplay of genetic, environmental, and behavioral factors. Serum uric acid (sUA) has been implicated in pathogenesis and maintenance of primary hypertension. However, insulin r...

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The paper presents a patient who was first diagnosed with hypertension just a few days before developing gout. Hypertension occurred along with the hyperuricemia last year after curing the patient of gout. Hyperuricemia was initially symptomatic and manifested as gout; later it was without its specific symptoms but was always associated with hypertension. Just a month after correction of the pa...

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Diuretics for hypertension.

A67-year-old African-American woman was referred to a hypertension specialty clinic for refractory hypertension and intermittent hypokalemia. Evaluations for primary aldosteronism and renal artery stenosis were negative; plasma renin was low. She had been hypertensive for 15 years. Most recently, she had taken chlorthalidone 25 mg, amlodipine 5 mg, and metoprolol 50 mg twice daily. She was not ...

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Thiazide diuretics in hypertension

Authors: Ferreira R. The use of diuretics (and beta-blockers) to treat hypertension has known a dramatic decline since the early 1980’s through to the early 1990s with the introduction of ACE-inhibitors and calcium channel blockers. However, thiazide diuretics are still a first line option to treat arterial hypertension, due to their efficacy and cost-effectiveness profile. We have presented ma...

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Uric acid and insulin sensitivity and risk of incident hypertension.

BACKGROUND Uric acid, insulin sensitivity, and endothelial dysfunction may be important in the development of hypertension. Corresponding circulating biomarkers are associated with risk of hypertension, but because these factors may be interrelated, whether they independently affect risk is unknown. METHODS In 1496 women aged 32 to 52 years without hypertension at baseline, we prospectively a...

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ژورنال

عنوان ژورنال: American Journal of Hypertension

سال: 2006

ISSN: 0895-7061

DOI: 10.1016/j.amjhyper.2006.03.013